2-Methyltetrahydrofuran (99.5%)
Product Profile
Apply for Sample| Names | |
|---|---|
| Preferred IUPAC name | Oxolane, 2-methyl- |
| Other names | 2-Methyl-THF 2-Methyl tetrahydrofuran 2-Methyltetrahydrofurane 2-Methyltetrafuran MeTHF |
| Pronunciation | /tuː-ˈmɛθ.əl.tɛ.trə.haɪ.drəˈfjʊə.ræn/ |
| Identifiers | |
| CAS Number | 96-47-9 |
| Beilstein Reference | 632514 |
| ChEBI | CHEBI:47777 |
| ChEMBL | CHEMBL1230412 |
| ChemSpider | 83101 |
| DrugBank | DB04414 |
| ECHA InfoCard | 40b6eac2-eab6-4661-93b6-8de4525366d5 |
| EC Number | 216-013-5 |
| Gmelin Reference | 86040 |
| KEGG | C01835 |
| MeSH | D000477 |
| PubChem CID | 10789 |
| RTECS number | LU5950000 |
| UNII | 35K15RGS8A |
| UN number | UN2660 |
| Properties | |
| Chemical formula | C5H10O |
| Molar mass | 86.13 g/mol |
| Appearance | Colorless liquid |
| Odor | ether-like |
| Density | 0.854 g/mL |
| Solubility in water | 14.2 g/100 mL (20 °C) |
| log P | 0.94 |
| Vapor pressure | 97 hPa (20 °C) |
| Acidity (pKa) | 25.8 |
| Basicity (pKb) | > 17 |
| Magnetic susceptibility (χ) | -7.34×10⁻⁶ cm³/mol |
| Refractive index (nD) | 1.406 |
| Viscosity | 0.46 cP (25 °C) |
| Dipole moment | 1.63 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 222.4 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -320.9 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -3220 kJ/mol |
| Pharmacology | |
| ATC code | 2-Methyltetrahydrofuran (99.5%)" does not have an ATC code. |
| Hazards | |
| GHS labelling | GHS02, GHS07, Danger, H225, H302, H336, P210, P261, P305+P351+P338, P337+P313 |
| Pictograms | GHS02, GHS07 |
| Signal word | Danger |
| Hazard statements | H226, H302, H319, H335, H336, H411 |
| Precautionary statements | P210, P261, P280, P301+P312, P304+P340, P312, P337+P313, P403+P235 |
| NFPA 704 (fire diamond) | 1-3-0 |
| Flash point | -11 °C |
| Autoignition temperature | 215 °C |
| Explosive limits | 1.55 - 12.2 % (V) |
| Lethal dose or concentration | LD50 Oral Rat 2000 mg/kg |
| LD50 (median dose) | LD50 (median dose): Oral rat LD50: 2000 mg/kg |
| NIOSH | TTI01870 |
| PEL (Permissible) | PEL (Permissible Exposure Limit): 100 ppm |
| REL (Recommended) | 100 ppm |
| IDLH (Immediate danger) | The IDLH for 2-Methyltetrahydrofuran (99.5%) is "2000 ppm". |
| Related compounds | |
| Related compounds | Tetrahydrofuran 2,5-Dimethyltetrahydrofuran Gamma-Butyrolactone 1,4-Butanediol Furan |
Chemical ID: CAS Formula HS Code Database
Product Identification: 2-Methyltetrahydrofuran (99.5%)
| Property | Technical Commentary |
|---|---|
| Product Name | 2-Methyltetrahydrofuran |
| IUPAC Name | 2-Methyloxolane |
| Chemical Formula | C5H10O |
| Synonyms & Trade Names | MeTHF, 2-MethylTHF, 2-Methyl-THF |
| CAS Number | 96-47-9 |
| HS Code & Customs Classification | 2932.19 (Cyclic Ethers and Their Derivatives) |
Technical Interpretation from Manufacturing Perspective
The identity and classification of 2-Methyltetrahydrofuran draw on consistent handling during manufacturing, customs declaration, and quality system control. Actual grade varies: solvents marked as 99.5% emphasize application-driven purity, with impurity tolerances targeted to suit pharmaceutical, specialty polymer, or fine chemical formulations. CAS number reference provides traceability essential for regulatory reporting and downstream technical dossiers.
Our production lines select raw materials based on minimum precursor byproduct profiles to minimize downstream purification loads. Sourcing and batch traceability are maintained through robust ERP systems, especially when demand shifts toward low-moisture or highly-reactive-grade MeTHF. Each variant shares a common chemical backbone but diverges in requirements for water control and stabilizer content depending on user need—from battery electrolytes to API synthesis.
Customs codes reflect both product structure and regulatory context. For 2-Methyltetrahydrofuran, consistent use of the 2932.19 heading streamlines cross-border logistics and aligns with inspection protocols at most major entry points. This reduces the frequency of customs clarification, ensuring supply chain fluidity for customers with just-in-time manufacturing requirements.
Technical Properties, Manufacturing Process & Safety Guidelines
2-Methyltetrahydrofuran (99.5%)
Physical & Chemical Properties
Physical State & Appearance
2-Methyltetrahydrofuran, in its standard transportation and storage form, is a clear, volatile liquid with an ether-like odor. Presence of moisture, oxygen, or improper packaging quickly leads to deterioration in appearance and functional purity. With standard grade, residual color should not be significant. Boiling point generally falls into the range that allows convenient removal via distillation, but users working at scale should verify for their specific grade and atmospheric conditions, especially under varying pressure regimes. Melting point determination is infrequently employed in process settings for this solvent, as crystallization is not an operational risk in most climates.
Chemical Stability & Reactivity
This ether shows pronounced susceptibility to peroxide formation on contact with atmospheric oxygen, requiring fresh material or regular analytical verification in storage—particularly in applications sensitive to peroxides. Heat, light, and extended exposure to air accelerate both polymerization and peroxide generation, especially with recycled or improperly stored lots. Reactivity with strong oxidants, and in acid-catalyzed or strong base-promoted reactions, is well documented in process safety literature and should be accounted for in process planning.
Solubility & Solution Preparation
Solubility in water is moderate and differs based on product grade; salts and residual stabilizers can influence phase separation and filtration during solution preparation. Prospective users should establish compatibility with water and organic phases for each target system to avoid stratification or emulsion formation in downstream steps. Routine analyses of water content are standard, since excessive water can interfere during reactions or extractions, especially in organometallic and anhydrous settings.
Technical Specifications & Quality Parameters
Specification Table by Grade
Most industrial users differentiate between 2-MTHF grades for pharmaceutical, electronic, or standard chemical applications. Purity requirements, particularly for residual moisture, peroxides, and non-volatile residues, often vary by customer application. Higher grades for sensitive synthesis demand documented absence of specific contaminants, while process solvent grades may tolerate greater levels of water or organic residues.
| Parameter | Typical Range (grade-dependent) | Test Method Reference |
|---|---|---|
| Purity (GC) | Up to 99.5% for high-purity applications | Gas Chromatography |
| Water Content | Application-dependent; Karl Fischer method preferred | Karl Fischer Titration |
| Peroxide Content | Routine testing required, especially after extended storage | Colorimetric Test |
| Non-Volatile Matter | Grade and application determine limits | Evaporation & Residue Weighing |
Impurity Profile & Limits
Key impurities stem from incomplete ring closure, solvent recovery contamination, or side-reactions in catalytic hydrogenation. Common contaminants include residual furanics, saturated ethers, and water. Upper specification limits reflect process consistency and must be matched to the user's tolerance for catalytically active trace metals or organic residuals. Targeted applications may specify additional analyses for halides, amines, or inorganics.
Test Methods & Standards
Gas chromatography remains the reference method for purity and major organic impurities. Moisture quantification by Karl Fischer titration remains industry standard, with periodic revalidation of method accuracy for each new batch or shipping container. For regulatory and safety compliance, peroxides require colorimetric or titrimetric testing with test frequency increasing in parallel with storage duration. Users with specialized needs may request nitrogen, metal, or particle analysis.
Preparation Methods & Manufacturing Process
Raw Materials & Sourcing
Feedstock typically derives from biomass or petrochemical butadiene sources. Where renewable certification is required, feedstock traceability protocols ensure verification of supplier chain. Raw butanediol purity directly influences process yield, especially in catalytic hydrogenation or dehydration approaches; close supplier engagement reduces batch variability and off-spec generation.
Synthesis Route & Reaction Mechanism
Main industrial routes rely on hydrogenation of furfural or acid-catalyzed cyclization of butanediol. Each synthesis path entails distinct impurity risks: with hydrogenation, trace furanics persist; with cyclization, dehydration byproducts are principal concerns. Catalyst choice drives selectivity and impurity profile, with supported noble metals or acids commonly in use.
Process Control & Purification
Process control focuses on temperature regulation, contact time, and feed composition to prevent runaway reactions or off-flavor organics. In-process GC analytics and colorimetric tests safeguard against accumulation of peroxides or heavy ends. Distillation, scrubbing, and molecular sieving target removal of high-boiling residues and water, while activated alumina or inert-gas sparging reduce peroxide risks ahead of definitive packaging.
Quality Control & Batch Release
Release of each batch follows documented GC fingerprinting, moisture quantification, and, where customer or market demands, expanded test suites for trace metals, acids, or stabilizers. Revalidation of key parameters takes place following any change in raw material source or process regime. Final criteria are set by internal manufacturing policy combined with customer application risk assessment.
Chemical Reactions & Modification Potential
Typical Reactions
As a solvent, 2-MTHF sees extensive use in organometallic and lithium-based chemistries, where water and trace peroxide pose the greatest risk of adverse reactivity. Formation of peroxides, ring-opening reactions under acid or Lewis acid conditions, and hydrogenation to pentanols represent the main reactivity domains that shape workup and downstream purification.
Reaction Conditions
Application-dependent pre-drying and de-oxidizing of solvent are essential for sensitive synthesis, especially in pharmaceutical and fine chemical sectors. Catalytic systems sensitive to moisture require rigorous drying protocols. User must verify solvent compatibility for each intended catalyst system and temperature/pressure regime based on batch and grade variability.
Derivatives & Downstream Products
Industrially, 2-MTHF is converted to alcohols, halides, or polymer building blocks through direct or stepwise modification. Capture and isolation strategies for downstream intermediates mandate low impurity backgrounds, consistent proton availability, and minimal illustration of peroxides or colored bodies.
Storage & Shelf Life
Storage Conditions
Storage demands a dry, well-ventilated, inert atmosphere; nitrogen blanketing is mandatory for high-purity applications. Protection from direct sunlight and elevated temperature suppresses peroxide formation and reduces risk of pressure build-up in sealed drums. Frequent analytical checks after extended storage flag any sign of peroxide, moisture ingress, or off-odors.
Container Compatibility
Stainless steel, specialized coated drums, and lined bulk containers best prevent unwanted solvent-metal reactivity and container-derived contamination. Long-term storage in mild steel or in containers with elastomeric seals can introduce catalytically active impurities; customer use cases may dictate specific packaging configurations to minimize off-label migration or vapor loss.
Shelf Life & Degradation Signs
Shelf life reflects both chemical purity and operational safety. Signs of degradation include color darkening, odor shift toward acrid notes, and positive peroxide indicator readings. Storage periods should not exceed manufacturer recommendations for the given grade, and visual plus analytical verification should precede release to critical applications.
Safety & Toxicity Profile
GHS Classification
2-Methyltetrahydrofuran is classified as a flammable liquid, with health and environmental hazard statements determined by its acute toxicity, inhalation risks, and potential for peroxide-related incidents. Hazard pictograms and precautionary statements must align with regulatory requirements and product purity.
Hazard & Precautionary Statements
Standard warnings direct handlers to avoid ignition sources, use protective gloves, and ensure effective ventilation. Peroxide formation risk underscores the need for periodic monitoring, especially after drum opening or protracted warehouse stays. Accidental contact or inhalation requires prompt decontamination—facility respiratory and skin protection standards must meet the solvent’s known irritation and short-term toxicity profiles.
Toxicity Data
Oral and inhalation toxicity data, where available, guide occupational exposure standards. Toxicological endpoints align with main ether solvents but may vary by impurity content, batch composition, or co-exposure with other chemicals.
Exposure Limits & Handling
Facilities rely on established national and international exposure guidelines. Engineering controls, such as fume extraction and vapor detection, support routine handling. PPE requirements escalate for higher-purity or peroxide-prone grades. All waste and spill protocols require reference to updated internal and regional authority safety data.
Supply Capacity & Commercial Terms
Production Capacity & Availability
Our production of 2-Methyltetrahydrofuran at 99.5% minimum purity draws on continuous-feed reactors designed for high-throughput batch consistency. Actual availability fluctuates by season, upstream plant maintenance, and regional sourcing of raw materials like 2-methylfuran. For most contract volumes, we align available tonnage with forecasted downstream demand, prioritizing sectors with tighter specification requirements—such as pharmaceutical or polymer applications—over solvent and extraction uses. Lead allocation reflects customer volume, purchase history, and required certificate of analysis (CoA) granularity.
Lead Time & MOQ
Typical lead time varies depending on purification schedule and blending logistics. For standard grades, shipment can commence within 7–15 days after confirmation, assuming prerequisite solvent-grade or higher requirements. Larger volumes, specialty grades, or bespoke packaging requests have longer consolidation and QC timelines. Minimum order quantities depend on tank or drum sizing protocols, with stock commonly available by the isotainer, 200L drum, or 1,000L IBC. Non-standard packs require dedicated filling and clearance slots.
Packaging Options
We offer shipment in lined drums, composite IBCs, and bulk isotainers. Grade-specific labeling and batch-level traceability are maintained through barcode-driven internal control. Pharmaceutical or electronics applications demand low-moisture and ultra-clean packaging, which increases both cycle time and costs due to additional nitrogen blanketing or enhanced cleaning steps.
Shipping & Payment Terms
FOB, CIF, and DAP Incoterm arrangements are standard according to contract. Most international clients prefer L/C at sight or TT-based payment, with performance guarantees stipulated via inspection certificates. Regulatory-driven documentation, including REACH or TSCA, is supplied as per customer region. Restricted routes apply where carriage of flammable liquids exceeds infrastructure ratings or destination-specific safety standards.
Pricing Structure & Influencing Factors
Raw Material Cost Composition
Cost of manufacture is most sensitive to price swings in 2-methylfuran, a critical input derived from renewable or petrochemical-based furfural, whose pricing tightly tracks both maize-cob and industrial chemical feedstock markets. Hydrogenation catalyst sourcing and utilities cost (especially hydrogen and high-purity water) contribute significantly to total conversion cost. For pharmaceutical grade, additional purification, online moisture/contaminant monitoring, and high-precision distillation increase batch cost due to lower throughput and higher rejection rates.
Fluctuation Causes
Feedstock price changes, energy market instability, plant run-rate disruptions, and regulatory shifts in permitted emissions or solvent recovery efficiency drive short-cycle price volatility. Upstream force majeure events, harvest variability for biomass-derived feedstocks, or sudden capacity shutdowns shift spot prices disproportionately.
Graded Price Differences
Grade, purity, and packaging certificate drive final sale price. Solvent and industrial grades, typically at 99.0–99.5%, command a different bracket from electronic or pharmaceutical grades, where water and peroxide impurity limits require extra filtration and certification (such as cGMP, USP, or EU Ph. Eur.). Packaging for sensitive applications, such as moisture-barrier drums or argon-purged isotainers, incurs further cost. Orders demanding specific analytical validation or customer-tailored documentation result in custom price calculations.
Global Market Analysis & Price Trends
Global Supply & Demand Overview
Supply chains for 2-Methyltetrahydrofuran remain sensitive to consolidation or expansion of upstream 2-methylfuran production, particularly in China and India, who represent the largest source regions for raw feedstock. Demand in North America and Europe reflects industrial solvent, coating, and polymer markets, with OEL and residual solvent classification impacting adoption.
Key Economies Analysis
US: Regulatory compliance, driven by EPA and FDA standards, pushes demand for high-purity and traceable batches. Contract pricing relies on long-horizon blanket orders.
EU: REACH-compliance and Green Chemistry incentives affect sourcing strategy, favoring renewable origin material. Distributor layering inflates downstream price brackets.
Japan: Specialty chemical and electronics-driven segment demands lowest trace impurity grades and certified shipment. Lead time spikes coincide with technology release cycles.
India: Aggressive expansion of both upstream furfural and hydrogenation clusters. Lower labor and utility costs retain local price advantage, but import tariffs and GST remittance affect landed cost for overseas buyers.
China: Production scale leads global spot supply, but export curbs, government quotas and safety compliance have strong impact on availability and offer validity period.
2026 Price Trend Forecast
The pricing outlook for 2026 remains exposed to feedstock supply security, tightening environmental audits, and expansion of downstream polyamide and active pharmaceutical ingredient manufacturing. Long-term contracts are increasingly favored for high-grade material, locking in current benchmarks plus escalation clauses where hydrogen and energy indexation applies. Spot pricing volatility is forecast to increase in regions with rapidly shifting environmental or trade policy.
Data Sources & Methodology
Market assessment aligns proprietary production data, direct customer volume movement, and secondary trade data from ICIS, ChemAnalyst, and government statistical releases. Cost structure benchmarks are verified by internal quality control results and feedback from regular audit processes.
Industry News & Regulatory Updates
Recent Market Developments
Expansion and debottlenecking of hydrogenation plants in Southeast Asia signal coming shifts in exportable volumes. Recovery-focused legislation in the EU is pushing preferred supplier networks toward lower emission, renewable-based supply, increasing scrutiny on cradle-to-gate emission tracking.
Regulatory Compliance Updates
Stricter VOC and solvent emission standards in Western Europe and North America mandate not only lower residual hydrocarbon content but also increased QA documentation on lot release. In Asia, harmonization of export approval and environmental release standards raises the bar on both batch monitoring and reporting.
Supplier Response & Mitigation
Investments in real-time batch analytics and impurity mapping provide improved early detection and lot segregation. Modular capacity expansions and flexible purification lines enable rapid response to regulatory swings and tailored customer certificate profiles. Emphasis on raw material traceability supports both compliance and defensible supply continuity.
Application Fields & Grade Selection Guide for 2-Methyltetrahydrofuran (99.5%)
Industry Applications
Technical teams across several industries rely on 2-Methyltetrahydrofuran (2-MeTHF) for roles that demand both solvent power and resistance to water. In pharmaceutical synthesis, it often replaces tetrahydrofuran as it simplifies extraction and drying steps, especially when low-boiling ethers with higher water tolerance benefit the process. In agrochemical formulations, manufacturers use it for solubilizing active ingredients and intermediates. High-purity grades see demand in battery electrolyte research, where moisture and peroxide content require close management, and in advanced material syntheses, selectivity during reactions makes process reproducibility crucial. Applications in flavor and fragrance production leverage the product for its clean extraction and low residue properties.
Grade-to-Application Mapping
| Application Field | Typical Grade | Key Requirements |
|---|---|---|
| Pharmaceutical Synthesis | 99.5% (Low moisture, low peroxides) | Consistent purity, low trace metal level, tight moisture spec, peroxide control |
| Agrochemical Processing | Technical Grade / 99.5% | Accepts wider residual solvent window, but batch consistency and impurity tracking are required |
| Battery Manufacturing | 99.9% Electronic/Anhydrous Grade* | Stringent water and acid limits, specific to lithium battery system, peroxide below detection |
| Fine Chemical/Flavor Extraction | 99.5% (Low odor, low byproduct) | Sensory clean profile, residual solvent limits, controlled handling to prevent cross-contamination |
*For applications involving batteries, consult directly for release specs that align with electrolyte system needs.
Key Parameters by Application
| Parameter | Criteria for Pharmaceutical | Criteria for Battery | Criteria for Agrochemical |
|---|---|---|---|
| Purity (% by GC) | ≥99.5, batch tested | ≥99.9, with water <50 ppm typical | ≥99.5, internally verified |
| Moisture (Karl Fischer) | <0.05%, custom on request | <0.005% where specified | <0.1% usually tolerated |
| Peroxide Content | Tracked below established risk level | Below detection limit, batch-certified | Monitored but broader limits allowed |
| Trace Metals | Controlled, documentation on request | Critical, requires advanced ICP-MS screening | Basic tracking on request |
Exact release levels for each parameter derive from both customer requirements and manufacturing route. In many cases, custom specifications are established through a joint qualification process, especially for regulated end uses.
How to Select the Right Grade of 2-MeTHF
Step 1: Define Application
The project scope determines purity and risk profile. Pharmaceutical synthesis targets regulated final products, demanding impurity profiles suitable for regulatory submissions. Applications in chemical manufacturing can accept wider impurity windows if downstream steps neutralize or remove trace contaminants.
Step 2: Identify Regulatory Requirements
Production bound for drug or food-related uses must comply with specific local regulations regarding residual solvents, impurities, and trace metals. Quality assurance teams maintain a register of current compliance specifications for REACH, FDA, and other authorities. For sectors not under formal regulation, customer procurement standards influence batch release.
Step 3: Evaluate Purity Needs
Technical-grade 2-MeTHF serves most extraction and industrial reaction setups. High-purity or anhydrous grades fit moisture and peroxide-sensitive chemistries, such as battery electrolytes or organometallic synthesis. For labs and pilot lines, batch consistency between orders becomes the deciding factor. Detailed certificates of analysis accompany every shipment, based on non-routine spot checks for critical parameters.
Step 4: Consider Volume & Budget
Batch volume shapes bulk handling, delivery mode, and unit cost. Small volume runs for laboratory and pilot batches may justify higher unit prices for tighter grades, while continuous operations calculate grade utility against downstream purification costs. Packaging choice can affect trace moisture and peroxide uptake during storage or transfer.
Step 5: Request Sample for Validation
Pilot testing with a production sample allows real-world evaluation of solvent compatibility, residue behavior, and impurity traceability. Manufacturing quality teams support customers in aligning the grade specification with process constraints. Documented observation of sample performance often shortens the technical qualification cycle and uncovers any process-specific compatibility gaps.
Trust & Compliance: Quality Certifications & Procurement Support for 2-Methyltetrahydrofuran (99.5%)
Quality Compliance & Certifications
Quality Management Certifications
Quality oversight in the production of 2-Methyltetrahydrofuran (2-MeTHF) demands documented controls from initial raw material assessment through batch approval. Our site maintains a quality management system aligned with recognized international standards relevant to chemical intermediates; compliance is audited periodically and supports traceable documentation. Certification status reflects the consistency of our process monitoring, contamination prevention, and incident response practices. Implementation depth varies by production facility and local regulations, with certain export destinations requiring explicit onsite audits or renewed third-party attestation.
Product-Specific Certifications
Certification requirements shift depending on the target application—pharmaceutical precursor, agrochemical, or specialty polymer solvent. Certain sectors require issued statements reflecting compliance with purity, impurity profile, or residual solvent content benchmarks. Our documentation typically includes results from validated GC/FID and GC/MS methods, alongside batch traceability and impurity fingerprinting. Where required by downstream application or end-user protocols, we provide evidence of compliance with relevant industry guidance or regional chemical regulations, and facilitate customer-driven audits or qualification samples.
Documentation & Reports
Technical documentation packages supplied for each batch include certificates of analysis (COA) with test method references, batch-specific analytical results, and, where relevant, chromatographic data to confirm residual impurity limits. Reports may also address storage stability study summaries, shipping conditions, and specific safety compliance declarations as contractually requested. Special project dossiers can be prepared for regulatory submissions or customer-specific change control, reflecting control of known genotoxic impurities and substantiating our in-process monitoring decisions.
Purchase Cooperation Instructions
Stable Production Capacity Supply and Flexible Business Cooperation Plan
Production consistency for 2-MeTHF reflects control at every unit operation, from choice of butadiene feedstock to purification, distillation, and finished product storage. Investment in flexibility—batch versus continuous operation, multi-grade scheduling, and raw material buffer inventory—allows responsiveness to seasonality, planned qualification lots, and campaign-specific runs. We work directly with buyers to synchronize production windows, minimum order sizes, safety stock, and supply buffer periods, minimizing risk to their downstream lines.
Core Production Capacity and Stable Supply Capability
Capacity planning stems from predictable cycle times and recovery yields at each production step. Plant-scale reactors are selected based on process intensification studies and customer volume forecasts. Core capacity is not assessed on nominal reactor size alone; it reflects synthesis route stability, impurity burden management (including catalyst management or fouling risks), and finished product tank capacity. Orders are prioritized based on binding allocation schemes for key contract accounts, with routine reporting on cycle time, major deviation logs, and back-inventory positions offered during high demand periods.
Sample Application Process
Sample requests are endorsed on the basis of application alignment, grade fit, customer technical evaluation requirements, and plant production window. Initial inquiry triggers a review of current onsite inventory and planned production campaigns; typical procedure involves small drum or pre-packed vial, accompanied by full COA and safety documentation. Our team collaborates with customer R&D or quality divisions to define test protocols or re-sampling needs, offering limited pilot-scale production for method development or scale-up trials where justified.
Detailed Explanation of Flexible Cooperation Mode
Supply models reflect business realities—long-term contract, spot supply, volume-flexible call-off, or consignment. Mode selection accounts for customer planning reliability, demand fluctuation, and logistics risk. For strategic alliances in regulated markets, our supply agreements build in contingency batch production, split delivery scheduling, and technical feedback loops to adapt to changing product or regulatory specifications. Our technical and sales support teams maintain regular review schedules with client purchasing and QC teams, minimizing surprises and supporting mutual contingency planning.
Market Forecast & Technical Support System for 2-Methyltetrahydrofuran (99.5%)
Research & Development Trends
Current R&D Hotspots
Industry R&D teams pay close attention to solvent performance in lithium battery electrolytes, biomass-derived production routes, and downstream reaction selectivity for pharmaceuticals and fine chemicals. Many customers require transparency regarding synthetic pathway—biomass-derived 2-MTHF versus petrochemical sources—due to regulatory and supply chain considerations. Process engineers from customer plants request detailed impurity profiles for the 99.5% grade, especially regarding peroxides and water content, due to the impact on reaction safety and product yield in both pharmaceutical synthesis and battery manufacturing.
Emerging Applications
Demand in battery manufacturing continues to expand as cell designers push for electrolyte systems with high polarity and lower viscosity. Crop protection and green chemistry reactions attract growing interest, particularly among customers preparing organometallic reagents and those requiring azeotropic removal of water. Solvent replacement programs in legacy pharmaceutical processing also prompt technical queries regarding process optimization and waste reduction strategies.
Technical Challenges & Breakthroughs
Process scale-up pushes development of improved peroxidation controls, especially as storage and transportation durations increase. Batch-to-batch consistency demands close monitoring of feedstock origins; impurities such as furans or saturated cyclic ethers require specification management according to customer use case. Recent improvements in continuous distillation and in-line water removal reduce residual moisture content during large-scale campaigns. Selective recycling of spent 2-MTHF, without compromising solvent performance, remains under pilot evaluation in several facilities.
Future Outlook
Market Forecast (3-5 Years)
Demand for 2-MTHF (99.5%) will likely remain strongest in Asia-Pacific, where large-scale battery, pharmaceutical, and specialty chemical synthesis sites continue significant expansion. Customer audits and qualification inspections increasingly favor traceable supply chains and manufacturer-owned production assets; this shapes plant investment and capacity planning. Both biomass and petro-derived production routes are supported in competitive regions, with biomass sources favored in regulatory-sensitive segments.
Technological Evolution
Solvent recovery and circular chemistry solutions mature as both regulatory and customer requirements shift. In manufacturing practice, continuous process improvements focus on impurity removal—particularly for peroxides, C4–C6 cyclic ethers, and polar residuals. Where pharmaceutical-grade 2-MTHF is required, further purification or additional water removal technologies, such as membrane separation or controlled drying columns, can be integrated after main distillation to meet downstream specifications.
Sustainability & Green Chemistry
Sustainable sourcing pressures drive cross-departmental discussions on bio-feedstock traceability, waste minimization, and process energy efficiency. Customers often seek full disclosure on both energy input and raw material life cycle footprint. To support green chemistry goals, R&D teams work with formulation chemists and process engineers to redesign upstream and downstream handling to maximize solvent recovery and minimize hazardous byproducts during both our production and customer use.
Technical Support & After-Sales Service
Technical Consultation
Technical support teams coordinate with customer QA/QC and process engineering offices to provide information on detailed impurity profiles, recommended storage protocols to minimize peroxide formation, and advice regarding compatibility with storage materials. Customer requirements regarding water content, residual acids, and peroxide controls are reviewed and validated against batch analytical data prior to shipment finalization.
Application Optimization Support
Direct exchanges with downstream process engineers identify critical control points where raw material variability could impact product yield or solvent recyclability. Pilot-scale sampling for new applications allows us to generate real-world data regarding performance in customer-specific syntheses or formulations. Where solvent recovery or distillation is conducted at customer sites, support covers both impurity carryover mitigation and feedback regarding technical improvements to optimize their process.
After-Sales Commitment
Our after-sales service teams maintain archives of batch analysis, supply detailed product use guidance, and provide ongoing access to technical experts for customer troubleshooting. Product recall scenarios and batch non-conformance resolutions follow internally approved standard operating procedures, prioritizing both customer operations continuity and regulatory compliance. We maintain transparent communications regarding any process changes or impurity specification updates, with customer notification and qualification as part of our release criteria.
2-Methyltetrahydrofuran (99.5%): An Industrial Perspective from the Manufacturing Floor
2-Methyltetrahydrofuran (2-MeTHF) plays a central role in a wide range of manufacturing environments. As a chemical producer with hands-on operational experience, we see the growing shift in demand for sustainable and efficient solvents. This compound, with its 99.5% purity, draws attention because of its performance profile and adaptability. Everything we supply comes out of our reactors, built and controlled under our direct management—no intermediaries, no dilution of responsibility over purity or safety.
Key Industrial Roles
In the labs and process lines of pharmaceuticals, agrochemicals, and electronics manufacturing, 2-MeTHF serves as more than just a solvent. Our teams use it across a variety of synthesis steps, often replacing traditional ethers in Grignard and organolithium chemistry. Consistent evaporation characteristics and a stable boiling point reduce batch-to-batch variation, which engineers and chemists demand in scale-up and continuous production. Our experience working alongside innovators in lithium battery and resin technologies demonstrates that 2-MeTHF provides better handling of moisture, compared to other ethers, and improves overall yields in sensitive reactions.
Quality Control at Every Step
Quality assurance at plant level draws from feedback loops built into our production batches. Each lot of 2-MeTHF goes through chromatographic analysis and moisture quantification before exiting our factory. Manufacturing engineers check for compliance at every stage, not just at final product release. Defining and enforcing impurity limits below the 0.5% mark comes from decades refining our distillation infrastructure. Lab data, not assumptions, drive our product release process.
Packaging and Supply Chain Management
We run our own packaging units adjoining the reactors, filling 2-MeTHF into ISO tanks, steel drums, or custom containers based on downstream processing needs. Real-world handling—from drumlining to sealing and leak inspection—minimizes risk of contamination. Having authority over load scheduling lets us prioritize high-volume buyers, adjust lot sizes, and guarantee shipment intervals tailored to your plant intake rates. Logistics and documentation follow the regulatory standards required for international shipment without introducing third parties that could compromise the supply chain.
Technical Support for Industrial Integration
Our technical team brings plant-level expertise. Industrial buyers rely not just on specifications but also on solvent compatibility, process integration, and impurity management. We regularly participate in on-site trials or remote troubleshooting, reviewing critical parameters like solvent recovery, washout procedures, or instrument calibration, integrating directly with customer lines when needed. Real issues receive real answers, derived from operational experience at tonnage scale.
Business Value for Procurement and Production Teams
| Aspect | Our Approach |
|---|---|
| Production Oversight | Direct supervision at each process stage yields traceable consistency. |
| Cost Control | Vertically integrated manufacturing enables predictable pricing for long-term contracts. |
| Response Time | As producers, we cut lead times and provide reliable shipment scheduling. |
| Technical Depth | Advice and troubleshooting derive from real application know-how instead of generic advice. |
What Sets Factory Production Apart
Direct manufacturing brings tangible advantages for large-scale buyers. Production, testing, and packaging all operate within a single standard, managed in-house. This structure limits surprises in supply and aligns with the stringent controls required by the industries we serve. Years of investment in plant upgrades and quality systems—driven by feedback from our own customers—reinforce a focus on consistency and process optimization. The results deliver value you can measure on your own balance sheet.
Industrial FAQ
What are the recommended storage conditions and chemical compatibilities for 2-Methyltetrahydrofuran (99.5%)?
Environmental Controls for Storage
2-Methyltetrahydrofuran (2-MeTHF, 99.5%) comes off our lines with high purity, but that quality depends on disciplined storage once it leaves production. We recommend a storage environment that prevents high temperature swings, excessive humidity, ignition sources, and direct sunlight. Extended heat exposure accelerates peroxide formation and increases vapor pressure, which creates unnecessary handling risks. Flames, sparks, or static discharge in the storage zone jeopardize both personnel safety and product integrity.
We advise using tightly sealed, inert-lined containers constructed from stainless steel or compatible polymers. The material resists both the aggressive nature of 2-MeTHF and potential cross-contamination. Standard mild steel can lead to corrosion and instability due to the solvent’s polar, oxygenated structure. In our experience, avoiding exposure to air during transfers and long-term storage delays peroxide accumulation. If large volumes require storage over weeks, consider using a nitrogen or dry air blanket in headspace to suppress atmospheric oxygen ingress.
Compatibility with Other Chemicals
From a manufacturing standpoint, 2-MeTHF dissolves a wide variety of organics, which calls for disciplined segregation in chemical storage. Do not store near strong oxidizing agents, nitric acid, or peroxides. The presence of these materials heightens the risk of exothermic reactions, fire, and hazardous decomposition. Keep acids and bases in separate areas, since 2-MeTHF will degrade or react through acid-catalyzed pathways, producing potentially harmful byproducts and undercutting batch-to-batch reliability.
Within our production facilities, only approved plastic or steel tools handle this solvent, with no copper or aluminum contact. Both metals can catalyze degradation and peroxide formation. 2-MeTHF does not attack common fluorinated gaskets and PTFE-lined valves, so we maintain these in our drum filling lines. We recommend periodic cleaning and inspection of storage containers and handling lines, since peroxides and degradation products can accumulate unseen.
Fire Safety and Handling Routines
2-MeTHF vapors form explosive mixtures with air, with flammability comparable to or greater than common ethers. Our warehouses feature EX-rated fans, grounded equipment, and vapor detection alarms to eliminate static and early warning for vapor accumulation. Personnel always use non-sparking tools and wear antistatic PPE in all transfer operations.
Each time we tap or decant bulk product, our technical team samples for off-odors or visible turbidity—both are indicators of contamination or peroxide growth. If a container remains idle for several weeks, a lab check for peroxides comes before any further movement or production use. We take this so seriously because past industry incidents traced back to skipped lab checks and improper storage discipline. An insurance policy for your process is as simple as following these safe practices.
Supporting Clean, Reliable Supply Chains
True chemical quality doesn’t stop at the factory gate. Our responsibility extends through every drum we fill. By designing practical handling protocols and supporting partners with technical advice, we keep both purity and safety front of mind. The best way to guarantee process consistency, worker protection, and predictable results in the lab or plant is disciplined control from production through to final application. Detailed product and safety data sheets are always available from our team upon request.
Is 2-Methyltetrahydrofuran (99.5%)) available in bulk quantities and what are the lead times for delivery?
From direct manufacturing floors, questions about securing bulk quantities of 2-Methyltetrahydrofuran (2-MeTHF) at 99.5% arise regularly. Large-volume customers—working across pharmaceuticals, electronics, and fine chemicals—depend on material reliability and predictable delivery. Consistent, in-house production guarantees stock at scale. Our site runs multiple synthesis lines dedicated to 2-MeTHF with capacity tailored to the high-volume needs of industry.
Meeting Market Demand at Scale
We support orders ranging from drum lots through isotank truckloads. While projects using 200 liters monthly require a very different planning approach from 20,000 liters per order, our process management keeps both on track. Our logistics team works continuously to align our output with customer orders, full-truck and container shipments, and stable downstream supply. Facilities producing 2-MeTHF operate under standard operating procedures refined over years of running this chemistry at scale. This keeps the transition from raw material to finished solvent both efficient and locked in to specifications.
Environmentally-aware end users push for manufactured green solvents, particularly those that support process intensification and lower environmental impact. Most customers shifting away from traditional ethers choose 2-MeTHF for recyclability and effective performance in critical reactions. We respond to this shift, expanding production units and safeguarding uninterrupted output even in volatile raw material markets.
Lead Times: Transparency and Planning
Batches of 2-MeTHF often ship within a two to four week window, depending on real-time production schedules and the order volume. Our finished stocks usually cover demand for standard drum and tote sizes. For full-tank or export loads, we highlight forecast windows to help customers maintain continuous operations. During planned maintenance or surges in demand, temporary extensions can occur. Our planning team communicates these windows based on actual batch completion and logistics integration.
Some sectors—pharma, agrochemicals, battery manufacturing—face unplanned surges in their own plants. Our core commitment centers around up-to-date status on what’s immediately available and what requires run-to-order production. We grant access to weekly stock snapshots so procurement teams can match application timelines with shipments.
Direct Factory Engagement
Direct relationships make a clear difference in securing reliable 2-MeTHF supplies. Because we control every step, from reaction charging through distillation to filling and quality assurance, we minimize hold-ups and guarantee composition to spec before anything goes out. Our technical staff certifies each lot with full documentation. Customers running sensitive syntheses or GxP-regulated processes can request full QC/QA support or certifications tailored to their process.
Supply disruption is a risk facing any plant running continuous processes. Our investments in multi-line redundancy and buffer storage mean we can mitigate interruptions during force majeure incidents, raw material pricing swings, or transit snarls. Those relying on just-in-time inventory frequently leverage our safety stock and integrated distribution channels.
To summarize, our factory-direct channels secure unbroken supply lines for 2-MeTHF at high purity. Orders for drums, totes, or full-tank bulk draw from both routine lots and to-order process runs. Typical shipments range from two to four weeks, buffered by advance production scheduling and flexible warehousing. Direct communication between our technical team and customer sites keeps lead time expectations clear and supports uninterrupted operations.
What are the shipping classifications and regulatory documentation required for handling and transporting 2-Methyltetrahydrofuran (99.5%) internationally?
Direct Experience in Hazardous Chemical Logistics
Managing the global supply chain for 2-Methyltetrahydrofuran (99.5%) requires more than logistics know-how—it demands a full grasp of regulatory frameworks and responsible product stewardship. Our team manages every step, from drum filling to final customs clearance, and every shipment reflects our commitment to safety, traceability, and customer transparency.
UN Classification and Transport Labelling
2-Methyltetrahydrofuran holds a UN 2536 classification under the UN Recommendations on the Transport of Dangerous Goods. Recognized as a Class 3 flammable liquid, this product requires specialized handling on land, sea, or air routes. We ship under robust compliance, using UN-approved drums or IBCs that bear appropriate hazard labels and placards for clear identification. These labels must remain intact throughout transit; our loading and inspection routines always confirm this integrity before dispatch.
Required Regulatory Documentation
International shipments involve a carefully assembled documentation pack. Our documents meet the requirements for sea (IMDG), air (IATA), and road (ADR) transport. For every order leaving our factory, we provide:
- Up-to-date Safety Data Sheet (SDS) with full GHS classification and international regulatory citations.
- Certificate of Analysis (COA) from our QC laboratory, confirming actual batch purity and water content.
- Commercial invoice with full product description, UN number, and applicable harmonized code for customs clearance.
- Packing list with container ID, batch numbers, and net/gross weights for every shipment unit.
- Transport Emergency Card (TREM or Tremcard) for European ADR shipments.
- IMDG or IATA Dangerous Goods Declaration signed by certified staff, cross-referenced with each SDS revision.
Authorities in the receiving country may request extra documents or import permits. As the manufacturer, we assist consignees with any required technical dossiers, letters of conformity, End User Declarations, or import licence references.
Safe Packaging and Secondary Containment
Rigorous control over packaging quality prevents accidental release and cross-contamination. We fill product exclusively into tested steel drums or composite IBCs with certified closure systems. Each container gets a tamper-evident seal and shipment trace code. All units are loaded on ISPM 15 treated pallets, and shrink-wrapped to control movement during transit. We enforce strict temperature and separation guidelines for full containers; mixed loads never risk incompatible co-loading.
Continuous Training and Regulatory Updates
We run ongoing training in our shipping department covering the latest regulatory changes. When authorities issue updates to IMDG, IATA, or ADR rules, we integrate the changes into our standard procedures immediately. These investments guarantee that our documentation and labelling always match the current international standards, lowering risks at customs or port inspections.
Practical Solutions and Industry Input
Border delays, evolving national rules, and technical shipment queries from customs require a proactive approach. Our documentation team stays ready to clarify product identifiers or provide technical data packages by request. We engage with regulators and shippers to resolve conflicting requirements without holding up our customers’ supply chains. We also maintain a feedback loop with major ocean and air carriers, keeping aligned on evolving restrictions or preferred documentation formats to keep our clients’ production lines running smoothly.
This hands-on approach underpins every international shipment, ensuring 2-methyltetrahydrofuran moves securely, lawfully, and with full transparency from our site to your facility.
Technical Support & Inquiry
For product inquiries, sample requests, quotations or after-sales support, please feel free to contact me directly via sales3@liwei-chem.com, +8615365186327 or WhatsApp: +8615365186327